唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局分析 赵丽;肖建平;杨岚;郭彩琴 【期刊名称】《中国全科医学》 【年(卷),期】2015(18)27 【摘 要】目的：探讨妊娠中期唐氏筛查低风险但单项指标人绒毛膜促性腺激素（ HCG）水平异常增高妊娠妇女的妊娠结局，为唐氏筛查单项指标HCG水平异常进行临床咨询提供理论依据。方法选择2012年10月—2013年12月南京医科大学附属无锡妇幼保健院妊娠中期唐氏筛查低风险的单胎妊娠妇女212例为研究对象，其中单项指标HCG水平增高的妊娠妇女112例为试验组，HCG水平正常的妊娠妇女100例为对照组，随访其妊娠结局，观察两组异常妊娠情况（包括胎膜早破、巨大儿、胎儿畸形、胎盘异常）。结果试验组巨大儿、胎儿畸形、胎盘异常发生率均高于对照组（P<0.05）。两组胎膜早破发生率比较，差异无统计学意义（P>0.05）。试验组5例胎儿畸形中3例为胎儿心脏畸形、1例为胎儿肺囊腺瘤、1例经无创基因筛查提示唐氏综合征经羊水穿刺证实后引产；9例胎盘异常中6例为胎盘粘连、2例胎盘形态异常、1例胎盘早剥。结论妊娠中期唐氏筛查HCG水平增高与巨大儿、胎儿异常及胎盘异常等不良妊娠结局相关。%Objective To investigate pregnancy outcome of women with abnormal increased HCG level and low risk of Down's syndrome in the mid trimester of pregnancy,to provide theoretical basis for clinical consultation about abnormal HCG in Down's screening. Methods 212 pregnant women with low risk of Down's syndrome through Down's screening in the mid trimester of pregnancy in Wuxi hospital for maternal and child health care affiliated to Nanjing medical university during October 2012 to December 2013,were selected as study subjects,among whom 112 cases with abnormal increased HCG level were included in test group,the other 100 cases with normal HCG level were included in control group. Their pregnancy outcome was followed up, and the abnormal pregnancy ( premature rupture of membranes, macrosomia, fetal anomaly and anomaly of placenta)of two groups of cases was analyzed. Results Prevalence of macrosomia,fetal anomaly and anomaly of placenta among cases in test group were significantly higher than those among cases in control group,respectively(P<0. 05). There was no significant difference in prevalence of premature rupture of membranes between two groups( P>0. 05 ) . Among 5 fetal anomaly cases in test group,3 cases had cardiac abnormalitis,1 case had lung cystadenoma,1 case had suspected Down's syndrome by noninvasive gene screening,and Down's syndrome was proved by amniocentesis,then the case underwent odinopoeia. Among 9 cases with placental abnormality,6 cases had placental adherence,2 cases had placenta morphologic abnormality,and 1 case had placental abruption. Conclusion Abnormal increased HCG level in the mid trimester of pregnancy is related to adverse pregnancy outcomes such as macrosomia,fetal anomaly and anomaly of placenta. 【总页数】4页(P3304-3307) 【作 者】赵丽;肖建平;杨岚;郭彩琴 【作者单位】214002 江苏省无锡市，南京医科大学附属无锡妇幼保健院;214002 江苏省无锡市，南京医科大学附属无锡妇幼保健院;214002 江苏省无锡市，南京医科大学附属无锡妇幼保健院;214002 江苏省无锡市，南京医科大学附属无锡妇幼保健院 【正文语种】中 文 【中图分类】R714.2 【相关文献】 1.孕妇唐氏筛查结果中人绒毛膜促性腺激素增高与妊娠结局的关系分析 [J], 赵予韬;刘举珍;赵新明;蔡铁铁 2.唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局探讨 [J], 夏英华; 3.唐氏筛查单项指标异常者检出胎儿染色体异常16例的回顾分析 [J], 周登诗;陈志华;黄芳;钟进 4.唐氏筛查单项指标人绒毛膜促性腺激素水平增高孕妇妊娠结局探讨 [J], 夏英华 5.不同年龄孕妇妊娠中期唐氏筛查结果及妊娠结局比较 [J], 武蕴芳 因版权原因，仅展示原文概要，查看原文内容请购买 本文来源：https://www.wddqw.com/doc/b19cea5a7a563c1ec5da50e2524de518964bd326.html