LDH-5在非霍奇金淋巴瘤诊断与疗效监测中的作用 江铭磊;陈祝俊;卢仁泉;郭林 【期刊名称】《中国癌症杂志》 【年(卷),期】2013(000)001 【摘 要】Background and purpose:Lactate dehydrogenase isoenzyme 5 (LDH5) is the main enzyme in glycolysis, which catalyze the oxidation of lactate into pyruvate. This study aimed to investigate the level of serum lactate dehydrogenase 5 (LDH-5) in non-Hodgkin’s lymphoma (NHL) patients and evaluation of LDH-5 level determination in disease curative effect monitoring. Methods:LDH-5 level of NHL patients (n=105) and healthy controls (n=185) were detected by agarose gel electrophoresis and 28 cases patients were detected and statistically analyzed. Results:The serum LDH levels were significantly higher in NHL patients (10.38±3.52)% than that in healthy controls (7.89±2.67)% (P<0.01). The determinations after chemotherapy decreased progressively and have significant statistical difference (P<0.05). The LDH-5 expression is significant correlated with NHL prognostic index. Conclusion:LDH-5 detection has a promising role in disease curative effect monitoring assessment of NHL.% 背景与目的：乳酸脱氢酶(lactate dehydrogenase,LDH)是糖酵解中主要的酶,能够催化乳酸变成丙酮酸.本实验主要探讨乳酸脱氢酶同工酶-5(lactate dehydrogenase-5,LDH-5)在非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)患者血清中的表达量及在疗效监测中的作用.方法：利用琼脂糖凝胶电泳法,测定了105例NHL患者与185例健康对照者的血清LDH-5水平,对其中28例化疗患者进行血清LDH-5随访,并对数据进行统计学处理.结果：NHL患者血清LDH-5水平为(10.38±3.52)%,明显高于健康对照者的(7.89±2.67)%,差异有统计学意义(P<0.01).化疗有效的NHL患者,化疗前后测定结果显示,血清LDH-5水平呈递减趋势,不同疗效组间的结果差异有统计学意义(P<0.05).LDH-5含量与NHL预后指标具有相关性.结论：LDH-5在NHL诊断与疗效监测中有较好的临床应用价值. 【总页数】4页(P55-58) 【作 者】江铭磊;陈祝俊;卢仁泉;郭林 【作者单位】复旦大学附属肿瘤医院检验科，复旦大学上海医学院肿瘤学系，上海200032;复旦大学附属肿瘤医院检验科，复旦大学上海医学院肿瘤学系，上海200032;复旦大学附属肿瘤医院检验科，复旦大学上海医学院肿瘤学系，上海200032;复旦大学附属肿瘤医院检验科，复旦大学上海医学院肿瘤学系，上海200032 【正文语种】中 文 【中图分类】R733.4 【相关文献】 1.外周血IGF-Ⅰ水平检测在卵巢癌诊断和疗效监测中的作用 [J], 张月香;李秋丽;王承缙;祁珮 2.PIVKA-II和AFP在原发性肝癌中的诊断和疗效监测中的临床应用价值 [J], 胡晓菲;於建鹏;王钢胜 3.血清HA、HAS2在骨肿瘤辅助诊断及疗效监测中的价值 [J], 盛雨梦;杨翠霞;许静;刘鷖雯;何怡青;刘华;黄宜;胡嘉捷;崔练;高锋 4.HSP90α联合CA-724在胃癌诊断和疗效监测中的价值研究 [J], 张丽娇;杨雁鸿;周文文;王小玉;王真真;赵子舒 5.病原学筛查及C-反应蛋白、降钙素原和白细胞介素-6在小儿下呼吸道感染诊断及疗效监测中的应用 [J], 刘丹;秦垚;余珍燕 因版权原因，仅展示原文概要，查看原文内容请购买 本文来源：https://www.wddqw.com/doc/3e450e24aa8271fe910ef12d2af90242a895abcd.html