硫酸头孢喹肟脂质体的毒理学试验及安全性评价 吴海港;徐光科;胡静;刘锦妮;陈钦玺;张迎冰;姬万民;易本驰;马云 【期刊名称】《中国畜牧兽医》 【年(卷),期】2017(044)008 【摘 要】The purpose of this study was to evaluate the safety of the cefquinome sulfate liposomes by using the acute toxicity test,local irritation test and chronic toxicity test.The results showed that the LD50 of cefquinome sulfate liposomes was 639.73 mg/kg after intramuscular injection of its suspension and 95％confidence interval was 573.06 to 714.17 mg/kg.There was no significant stimulation to muscle.Subchronic toxicity test showed that the weight,haematological indexes and biochemical criterion of rabbits in variety dose had no significant difference compared with normal group(P>0.05).There was no visible pathological changes on the liver,kidney histology.According to pathological observation,the structure of liver and kidney were clear in treated and middle dose groups,but there existed disorganized hepatic cell cord in the liver and hemorrhag between glomerulopathy,tubulointerstitial and hepatic sinusoids in high dose group.All results proved that the cefquinome sulfate liposomes was safe and reliable based on the animal experiments.%采用急性毒性试验、局部刺激性试验和亚慢性毒性试验对硫酸头孢喹肟脂质体安全性进行评价,以期为临床用药提供参考.小鼠腹腔注射硫酸头孢喹肟脂质体半数致死量(LD50)为639.73 mg/kg,95％可信限为573.06～714.17 mg/kg;该制剂对家兔股四头肌未见明显刺激作用;各给药剂量组家兔的体重、血液学指标、生化指标与对照组比较均无显著差异(P>0.05);对肝脏和肾脏病理学观察表明,正常治疗剂量和中剂量组肝脏和肾脏组织结构清晰,但高剂量组出现肝细胞排列紊乱,肝血窦间出血,肾小球、肾间质有散在出血.以上结果表明硫酸头孢喹肟脂质体安全可靠,可应用于兽医临床. 【总页数】6页(P2523-2528) 【作 者】吴海港;徐光科;胡静;刘锦妮;陈钦玺;张迎冰;姬万民;易本驰;马云 【作者单位】信阳农林学院,信阳 464000;信阳农林学院,信阳 464000;信阳农林学院,信阳 464000;信阳农林学院,信阳 464000;信阳农林学院,信阳 464000;信阳农林学院,信阳 464000;瑞普(天津)生物科技股份有限公司,天津 300308;信阳农林学院,信阳 464000;信阳师范学院,信阳 464000 【正文语种】中 文 【中图分类】S859.7 【相关文献】 1.HPLC法测定硫酸头孢喹肟注射液中硫酸头孢喹肟含量 [J], 李勇军;杨海峰;蒋春茂;于生兰;张成;金礼琴;朱雄 2.硫酸头孢喹肟中间体3′-碘甲基头孢噻肟的合成 [J], 杨佳宁; 3.长效土霉素、头孢氨苄、硫酸头孢喹肟三种注射液对患病仔猪的疗效观察 [J], 李劲松;韦绍婉 4.HPLC法测定硫酸头孢喹肟冻干粉针中硫酸头孢喹肟含量 [J], 俞吉杰;余祖功;赵杰;刘利锋;段复康;江善祥 5.硫酸头孢喹肟中间体7氨基头孢喹肟氢碘酸盐的合成 [J], 武晓青;赵地顺;尚青;梁策 因版权原因，仅展示原文概要，查看原文内容请购买 本文来源：https://www.wddqw.com/doc/d883f9b8bbf67c1cfad6195f312b3169a451eae8.html