小檗碱壳聚糖缓释片的制备及其释放度测定 马频;张洪;颜丹萍 【期刊名称】《医药导报》 【年(卷),期】2017(036)011 【摘 要】目的 制备小檗碱壳聚糖缓释片并研究其体外释放特性.方法 采用壳聚糖骨架制备小檗碱壳聚糖缓释片,高效液相色谱法测定盐酸小檗碱在不同释放时间点的药物释放度.结果 小檗碱壳聚糖缓释片在体外随时间的延长释放度也增加,释放时间可持续24 h,且24 h累积释放度超过95%,溶出63.2%所需时间td=12.63 h.人工胃液对小檗碱的溶出效果最好,转速只影响小檗碱初期释放.结论 该方法方便、准确、重复性好,小檗碱壳聚糖缓释片具有进一步开发和应用价值.%Objective To prepare berberine chitosan sustained-release tablets and to study the in vitro release characteristics. Methods The chitosan sustained-release tablets were prepared by chitosan as the skeleton material,and the drug release rate of berberine hydrochloride at different time was determined by high performance liquid chromatography. Results The in vitro cumulative release of berberine chitosan sustained-release tablets was increased with time.Furthermore,it can sustain for 24 h and the accumulative release was above 95%, the dissolution time of 63. 2% of the drug was 12. 63 h. Artificial gastric juice had the best performance on the dissolution of berberine,while rotations only influenced the dissolution at the beginning of drug release. Conclusion This method is convenient, accurate and reproducible.Berberine chitosan sustained-release tablets have further development and application value. 【总页数】4页(P1291-1294) 【作 者】马频;张洪;颜丹萍 【作者单位】武汉大学人民医院药学部,武汉 430060;武汉大学人民医院药学部,武汉 430060;武汉大学人民医院药学部,武汉 430060 【正文语种】中 文 【中图分类】R286;TQ460.1 【相关文献】 1.穿心莲总内酯骨架缓释片的制备及释放度测定 [J], 李小芳;舒予;刘玲;文怡静;吴珊;尹帮龙 2.芦丁壳聚糖缓释片处方设计及体外释放度测定 [J], 陈丽;葛为公;裴世成;吴钢;李惠萍 3.盐酸小檗碱脂质体的制备及体外释放度测定 [J], 刘留成;陈国广 4.芦丁壳聚糖缓释片的制备与释放度测定 [J], 陈丽;葛为公;裴世成;李惠萍;吴钢 5.烟酸占替诺壳聚糖缓释片的研制及释放度测定 [J], 杨红梅;葛为公;曾立威 因版权原因，仅展示原文概要，查看原文内容请购买 本文来源：https://www.wddqw.com/doc/271b06b3920ef12d2af90242a8956bec0975a5b6.html